APVMA concludes its review of atrazine
The APVMA has announced the conclusion of its review into atrazine which supports its continued registration and use in Australia subject to label changes to further reduce the risk of contamination of waterways.
“The conclusion of this final component of the review will see the APVMA implement a small number of additional regulatory actions proposed in an interim report in 2004 whose effect will be to further tighten and better define restrictions applied since 1997,” Dr Simon Cubit, Manager Public Affairs, said.
“In addition, the APVMA has acted on new information suggesting a potential risk of atrazine entering waterways through the use of the chemical post-emergence on triazine tolerant canola in raised bed cropping systems. The APVMA is requiring registrants to collect data to enable it to further evaluate this issue,” Dr Cubit said.
Earlier concerns over human and animal carcinogenicity, environmental impacts and residue and efficacy uncertainties were addressed in 1997.
Recent debate in Australia and the US claimed atrazine may cause developmental effects in frogs. In both jurisdictions authorities have concluded that the weight of evidence does not support the claimed effects.
“The APVMA however recognises that the debate continues and will keep a watching brief on scientific developments. The APVMA has requested consideration by the Office of Chemical Safety (OCS) of one emerging line of research that proposes a new mode of action (MOA) for atrazine that has not previously been considered,” Dr Cubit said.
“Should a scientific consensus emerge or any of these new lines of research generate legitimate areas of concern, the APVMA will initiate a new review.”
Atrazine Final Review Report and Regulatory Decision is available on the APVMA website at
http://www.apvma.gov.au/chemrev/atrazine.shtml.
This follows on from the conclusions of the US EPA in October last year:
The USEPA produced a white paper on the potential effects of atrazine on amphibian gonadal development - this was considered at a meeting of their Science Advisory Panel on October 9-12, 2007.
Here is a copy of their ‘CONCLUSIONS FROM LABORATORY AND FIELD STUDIES’
‘The Agency has reviewed 36 open literature and registrant-submitted studies related to the potential effects of atrazine on gonadal development in amphibians. Overall, the weight-of-evidence based on these studies does not show that atrazine produces consistent, reproducible effects across the range of exposure concentrations and amphibian species tested. In laboratory studies where environmental and animal husbandry factors were controlled, atrazine exposures (0.01 - 100 ug/L) did not affect time to or size at metamorphosis, sex ratio, or gonadal development. While there were several effects on secondary gross and histological endpoints that were statistically significant, their relationship to apical endpoints of intersex and/or gonadal development effects is not considered relevant.
Because of the uncertainties associated with all the laboratory and field studies conducted prior to 2003, the 2003 SAP recommended that additional studies be conducted to determine if exposure to atrazine affects amphibian gonadal development. In their report, the SAP recommended using X. laevis as the test species as well as indigenous species. Because the SAP report did not identify what benefits the indigenous species would provide, the Agency concluded that testing with X. laevis would be sufficient for a Tier 1 study.
Based on the recent nineteen studies reviewed, including the recently submitted DCI studies showing no effects of atrazine on amphibian gonadal development, the Agency has further concluded that the higher tiers of testing proposed in the 2003 White Paper (USEPA 2003) are not needed at this time’.
http://www.epa.gov/scipoly/sap/meetings/2007/october/2007_amphibian_white_paper.pdf
Those who have a different view on the environmental effects of atrazine cannot claim that the APVMA or the US EPA have ignored their concerns. As stated above, the weight of evidence does not support those claims, but both organizations have signalled that they will continue to monitor developments.
Dr Barry Tomkins is an independent consultant and an Honourary Senior Fellow of the University of Melbourne. A chemist, he has a B. Sc. and Ph. D. from the University of Melbourne. He has carried out research in the development of new herbicides and herbicide mixes for possible use in plantation forestry for fifteen years. He conducts an independent collaborative program of small-scale and operational herbicide trials. The work is supported by nineteen forestry organisations including State departments, and by the research agricultural chemical companies. Every two years he conducts a plantation pest management seminar/workshop; the last one in February this year was attended by more than 100 representatives from plantation organisations, public authorities, research organisations and agricultural chemical companies. He is the co-author with Braden Jenkin of a major Forest and Wood Products Australia report titled ‘The use of chemical pesticides by the Australian plantation forest industry’.
Dr Barry Tomkins
The Australian Pesticides and Veterinary Medicines Authority (APVMA) has announced the conclusion of its review into atrazine which supports its continued registration and use in Australia subject to label changes to further reduce the risk of contamination of waterways.
On May 6 Croplife Australia released the following commentary on the finalization of the APVMA’s review of atrazine and its uses…




















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